Cell properties of nucleus pulposus progenitor cells declines with intervertebral disc degeneration
نویسندگان
چکیده
منابع مشابه
Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc
Despite the high prevalence of intervertebral disc disease, little is known about changes in intervertebral disc cells and their regenerative potential with ageing and intervertebral disc degeneration. Here we identify populations of progenitor cells that are Tie2 positive (Tie2+) and disialoganglioside 2 positive (GD2+), in the nucleus pulposus from mice and humans. These cells form spheroid c...
متن کاملTransplantation of allogenic nucleus pulposus cells attenuates intervertebral disc degeneration by inhibiting apoptosis and increasing migration
Transplantation of nucleus pulposus cells (NPCs) into the intervertebral disc (IVD) has been demonstrated to be an effective treatment of degenerative disc disease (DDD). However, the underlying mechanisms have remained to be sufficiently elucidated. The aim of the present study was to explore the potential cell migration and anti‑apoptosis efficacy of NPCs in the treatment of DDD. NPCs culture...
متن کاملIntegrin β1 overexpression protects nucleus pulposus cells from apoptosis and attenuates intervertebral disc degeneration
Intervertebral disc (IVD) degeneration is a chronic pathologic process characterized by excessive apoptosis of intervertebral disc cells. The purpose of the current study was to detect the effect of integrin β1 on apoptosis of NP cells and IVD degeneration. Integrin β1 overexpressing lentivirus vector (LV-ITG β1) was constructed and transduced to NP cells, and its effect on cell apoptosis were ...
متن کاملMesenchymal stem cells deliver exogenous miR‐21 via exosomes to inhibit nucleus pulposus cell apoptosis and reduce intervertebral disc degeneration
Although mesenchymal stem cells (MSCs) transplantation into the IVD (intervertebral disc) may be beneficial in inhibiting apoptosis of nucleus pulposus cells (NPCs) and alleviating IVD degeneration, the underlying mechanism of this therapeutic process has not been fully explained. The purpose of this study was to explore the protective effect of MSC-derived exosomes (MSC-exosomes) on NPC apopto...
متن کاملIntervertebral Disc Restoration Following Reduced Nucleus Pulposus Glycosaminoglycan in an Animal Model of Early Degeneration
3 Department of Orthopaedics, Bronx-Lebanon Hospital Center, Albert Einstein College of Medicine, Bronx, NY A lack of understanding of the degeneration process has limited treatments aimed at halting or reversing intervertebral disc degeneration. An animal model that replicates key features of human disc degeneration is needed for both elucidating the mechanisms as well as for preclinical testi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Oncotarget
سال: 2017
ISSN: 1949-2553
DOI: 10.18632/oncotarget.23029